Genesis and pathogenesis of lymphatic vessels.
Identifieur interne : 008E92 ( Main/Exploration ); précédent : 008E91; suivant : 008E93Genesis and pathogenesis of lymphatic vessels.
Auteurs : Michael Jeltsch [Finlande] ; Tuomas Tammela ; Kari Alitalo [Finlande] ; Jörg WiltingSource :
- Cell and tissue research [ 0302-766X ] ; 2003.
Descripteurs français
- KwdFr :
- Animaux, Endothélium lymphatique (anatomopathologie), Endothélium lymphatique (métabolisme), Humains, Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Maladies lymphatiques (anatomopathologie), Maladies lymphatiques (métabolisme), Néovascularisation pathologique (anatomopathologie), Néovascularisation pathologique (métabolisme), Récepteur-3 au facteur croissance endothéliale vasculaire (génétique), Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme), Système lymphatique (), Système lymphatique (anatomopathologie), Système lymphatique (métabolisme), Tumeurs du tissu vasculaire (anatomopathologie), Tumeurs du tissu vasculaire (métabolisme).
- MESH :
- anatomopathologie : Endothélium lymphatique, Lymphoedème, Maladies lymphatiques, Néovascularisation pathologique, Système lymphatique, Tumeurs du tissu vasculaire.
- génétique : Récepteur-3 au facteur croissance endothéliale vasculaire.
- métabolisme : Endothélium lymphatique, Lymphoedème, Maladies lymphatiques, Néovascularisation pathologique, Récepteur-3 au facteur croissance endothéliale vasculaire, Système lymphatique, Tumeurs du tissu vasculaire.
- Animaux, Humains, Système lymphatique.
English descriptors
- KwdEn :
- Animals, Endothelium, Lymphatic (metabolism), Endothelium, Lymphatic (pathology), Humans, Lymphatic Diseases (metabolism), Lymphatic Diseases (pathology), Lymphatic System (blood supply), Lymphatic System (metabolism), Lymphatic System (pathology), Lymphedema (metabolism), Lymphedema (pathology), Neoplasms, Vascular Tissue (metabolism), Neoplasms, Vascular Tissue (pathology), Neovascularization, Pathologic (metabolism), Neovascularization, Pathologic (pathology), Vascular Endothelial Growth Factor Receptor-3 (genetics), Vascular Endothelial Growth Factor Receptor-3 (metabolism).
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor Receptor-3.
- blood supply : Lymphatic System.
- metabolism : Endothelium, Lymphatic, Lymphatic Diseases, Lymphatic System, Lymphedema, Neoplasms, Vascular Tissue, Neovascularization, Pathologic, Vascular Endothelial Growth Factor Receptor-3.
- pathology : Endothelium, Lymphatic, Lymphatic Diseases, Lymphatic System, Lymphedema, Neoplasms, Vascular Tissue, Neovascularization, Pathologic.
- Animals, Humans.
Abstract
The lymphatic system is generally regarded as supplementary to the blood vascular system, in that it transports interstitial fluid, macromolecules, and immune cells back into the blood. However, in insects, the open hemolymphatic (or lymphohematic) system ensures the circulation of immune cells and interstitial fluid through the body. The Drosophila homolog of the mammalian vascular endothelial growth factor receptor (VEGFR) gene family is expressed in hemocytes, suggesting a close relationship to the endothelium that develops later in phylogeny. Lymph hearts are typical organs for the propulsion of lymph in lower vertebrates and are still transiently present in birds. The lymphatic endothelial marker VEGFR-3 is transiently expressed in embryonic blood vessels and is crucial for their development. We therefore regard the question of whether the blood vascular system or the lymphatic system is primary or secondary as open. Future molecular comparisons should be performed without any bias based on the current prevalence of the blood vascular system over the lymphatic system. Here, we give an overview of the structure, function, and development of the lymphatics, with special emphasis on the recently discovered lymphangiogenic growth factors.
DOI: 10.1007/s00441-003-0777-2
PubMed: 12942362
Affiliations:
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Le document en format XML
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xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Système lymphatique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic system is generally regarded as supplementary to the blood vascular system, in that it transports interstitial fluid, macromolecules, and immune cells back into the blood. However, in insects, the open hemolymphatic (or lymphohematic) system ensures the circulation of immune cells and interstitial fluid through the body. The Drosophila homolog of the mammalian vascular endothelial growth factor receptor (VEGFR) gene family is expressed in hemocytes, suggesting a close relationship to the endothelium that develops later in phylogeny. Lymph hearts are typical organs for the propulsion of lymph in lower vertebrates and are still transiently present in birds. The lymphatic endothelial marker VEGFR-3 is transiently expressed in embryonic blood vessels and is crucial for their development. We therefore regard the question of whether the blood vascular system or the lymphatic system is primary or secondary as open. Future molecular comparisons should be performed without any bias based on the current prevalence of the blood vascular system over the lymphatic system. Here, we give an overview of the structure, function, and development of the lymphatics, with special emphasis on the recently discovered lymphangiogenic growth factors.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Tammela, Tuomas" sort="Tammela, Tuomas" uniqKey="Tammela T" first="Tuomas" last="Tammela">Tuomas Tammela</name><name sortKey="Wilting, Jorg" sort="Wilting, Jorg" uniqKey="Wilting J" first="Jörg" last="Wilting">Jörg Wilting</name></noCountry><country name="Finlande"><noRegion><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name></noRegion><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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